Liliya Yamaleyeva, MD, MS
Postdoctoral Research Fellow
Education: M.D. General Medicine Bashkir State Medical University, Ufa, Russia (1992)
Residency in Internal Medicine Clinical Hospital No. 21, Ufa, Russia (1992-1993)
M.S. in Biomedical Sciences Research Eastern Virginia Medical School, Norfolk, VA (2002)
Laboratory Department: Hypertension and Vascular Disease Center
Email: lyamaley@wfubmc.edu
Advisor: Dr. Mark. Chappell
Current Research:
My research interest is in gender differences in cardiovascular and renal physiology, particularly the role of estrogen and salt in the regulation of blood pressure, renal function and renal injury. By applying biochemical assays and in vivo experimental techniques I have characterized the effects of estrogen on renal nitric oxide synthase (NOS) and cyclooxygenase (COX) in salt-sensitive hypertensive female mRen2.Lewis rat, a model of renin overexpression. My research also focuses on the interaction between various components of the renin-angiotensin system, NOS and COX since a dysbalance of these systems may further contribute to the exacerbation of blood pressure and renal injury.
Awards:
08/2005 COSEHC Travel Award for poster presentation at Consortium For Southeastern Hypertension Control (COSEHC) Poster Session, August 2005, Nashville, TN
04/2005 The Caroline tum Suden/ Francis A. Hellebrandt Professional Opportunity Award, $500 cash prize, American Physiological Society
10/2004 Silver Prize, Basic Science Fellow category, Wake Forest University Health Sciences, Division of Surgical Sciences, 12th Annual Residents’ and Fellows’ Research Day, 2004
2002-2003 Annual Eastern Virginia Medical School Scholarship
10/2002 1st prize from Cardiovascular and Renal Research Center, Eastern Virginia Medical School, 14th Annual Students’ and Fellows’ Research Day
Publications:
Papers In Refereed Journals
Yamaleyeva L.M., Gallagher P.E, Vinsant S., Chappell M.C., “Discoordinate regulation of renal nitric oxide synthase isoforms in congenic mRen2.Lewis rats following ovariectomy.” Am J Physiol Regul Integr Comp Physiol. 2006 Oct 5 (in press).
Chappell M.C., Yamaleyeva L.M., Westwood B.M., “Estrogen and salt-sensitivity in the female congenic mRen2.Lewis rat.” Am J Physiol Regul Integr Comp Physiol. 2006 Nov; 291(5):R1557-63.
Conference Proceedings and Abstracts
Yamaleyeva L.M., Westwood B.M., Gallagher P.E., Vinsant S., Chappell M.C., “Protective roles for neuronal nitric oxide synthase (nNOS) and cyclo-oxygenase2 (COX2) in the salt-sensitive female mRen2.Lewis rat.” FASEB Journal 20 (5): A1192-A1192 Part 2, Mar 7 2006.
Yamaleyeva L.M., Westwood B.M., Groban L., Chappell M.C., “Ovariectomy is protective against salt-induced renal injury in the older female mRen2.Lewis strain”, Hypertension 2006, 48[e28].
Yamaleyeva L.M., Gallagher P.E., Averill D.B., Ferrario C.M., Westwood B.M., Chappell M.C., “Failure to upregulate nNOS may exacerbate renal injury in estrogen-depleted, high-salt fed mRen2.Lewis rats.” FASEB J 18(4); A108 (350.11), 2005.
Westwood B.M., Yamaleyeva L.M., Averill D.B., Ferrario C.M., Groban L., Chappell M.C., “Gender differences in response to combined ACE/AT1 blockade in the salt-sensitive mRen2.Lewis rat.” FASEB J 18(4); A112 (350.15), 2005.
Groban L., Westwood B.M., Averill D.B., Ferrario C.M., Yamaleyeva L.M., Chappell M.C., “Estrogen depletion exacerbates diastolic dysfunction in the salt sensitive female mRen2.Lewis strain.” Hypertension 46(4); 819 [27], 2005.
Yamaleyeva L.M., Vinsant S., Averill D.B., Ferrario C.M., Westwood B.M., Gallagher P.E., Chappell M.C., “The influence of nitric oxide synthase I (nNOS) on the estrogen-dependent control of blood pressure in the female mRen2.Lewis strain.” Hypertension 46(4); 858 [149], 2005.
Chappell M.C., Yamaleyeva L.M., Averill D.B., Ferrario C.M., Vinsant S., Westwood B.M., Gallagher P.E., “Discordinate regulation of aldosterone, renal COX-2 and NOS isoforms following estrogen depletion or high salt diet in the female mRen2.Lewis strain.” Hypertension 46(4); 818[22], 2005.
Yamaleyeva L., Gallagher P.E., Averill D.B., Ferrario C.M., and Chappell M.C. “DNA microarray analysis in the salt-sensitive, estrogen-depleted mRen2.Lewis rat,” Book of abstracts of Experimental Biology Meeting, 2004, Washington, DC.
Dobrian A. D. and Iamaleeva L., “Identification of a functional NAD(P)H oxidase in human renal proximal tubule epithelial cells (RPTEC): regulation by angiotensin 2 and PPAR g” Annual Virginia Nephrology Retreat, May 30, 2003, Richmond, VA.
Dobrian A. D. , Schriver S. D. , Iamaleeva L. M., and Prewitt R. L., “Identification of a functional NAD(P)H oxidase in human renal proximal tubule epithelial cells (RPTEC): regulation by angiotensin 2 and PPAR g agonists,” Book of abstracts of Experimental Biology Meeting, 2003, April 11-15, San Diego, CA.
Fathutdinov R. A. , Yamaleyeva L. M. , and Musharanov D. R., “Application of the acute pharmacodynamic test for evaluation of hemodynamic data for the patients with essential hypertension,” Proceedings of the Conference of Young Scientists on Problems in Theoretical and Practical Medicine, Ufa, 1998, pp. 69-70 (In Russian).
Basirova N. K., Gimranova Z. M. , and Yamaleyeva L. M., “Application of the reoencephalography method for estimation of the influence of nicotine on the cerebral hemodynamics”, Proceedings of the 62th Conference of Young Scientists, Ufa, 1997, pp. 71-73 (In Russian).
Avzaletdinova A.R. , Yamaleyeva L.M., Shachmametov R.A., and Shamin E.M., “Influence of EDNIT on the central hemodynamics of patients with stroke caused by the hypertension”, Transactions of Ufa Clinical Hospital No.5, Ufa, 1997, pp.67-69 (In Russian).
Oral Presentations:
60th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure, October 4-6, 2006; San Antonio, TX.
Experimental Biology Meeting, April 1-6, 2006, San Francisco, CA.
Wake Forest University Health Sciences, Obstetrics and Gynecology Perinatal Research Group Seminar Conference, October 19, 2005, Winston-Salem, NC
Experimental Biology 2004, April 17-21, Washington, DC.
Grant Support:
07/2005 – 07/2007 Postdoctoral Fellowship, Mid-Atlantic Affiliate of the American Heart Association. Title: “Effect of estrogen on renal nitric oxide synthase in salt-sensitive hypertensive mRen2.Lewis rat”. Amount: $70,000/2 years.