Kyle Carver
Second Year Graduate Student; 2007-2008
Education: BSE in Biomedical Engineering, 2005 at Case Western Reserve University
Graduate Program: Physiology and Pharmacology
Laboratory Department: Hypertension and Vascular Research Center
Email: kcarver@wfubmc.edu
Advisor: Dr. Ann Tallant
The physiology and pharmacology program at Wake Forest was attractive because of the versatility of laboratories one can join once here. I was able to experience exciting rotations in the Hypertension and Vascular Research Center as well as the Wake Forest Institute for Regenerative Medicine. Upon joining Dr. Tallant’s lab I have been allowed to work on cutting edge research involving our peptide of interest, Angiotensin (1-7), effects on vascular injury.
Current Research:
My research while working in Dr. Tallant’s lab has focused on the effects of Ang-(1-7) on the migration of vascular smooth muscle cells (VSMC). VSMC migration and proliferation are critical for the development of restenosis, the development of neointima, after vascular injury. Previous studies by Dr. Tallant have shown that neointima formation is reduced by Ang-(1-7) by its antiproliferative effects on VSMC. I am interested in determing if Ang-(1-7) has antimigratory effects on VSMC and the molecular mechanisms involved in the process. I am also interested in determining the molecular mechanisms to how Ang-(1-7) reduces proliferation of VSMC.
Publications:
Abstracts:
Carver KA, Wang Z, Delo DM, Soker S. Endothelial progenitor cells and VEGF increase neovascularization and volume preservation of engineered tissues in vivo. Graduate student research day, Wake Forest University. 2008
Carver KA, Newton SJ, Lesser GJ, Tallant EA, Gallagher PE. Inhibition of Human Glioblastoma Growth by Angiotensin-(1-7). Fifteenth Annual Residents’ and Fellows’ Research Day, Wake Forest Baptist Medical Center. 2007