Hossam Shaltout, PhD
Research Fellow
Education:
B.Sc Pharmacy 1993, University of Alexandria, Egypt.
MS Pharmacology, 2000, School of Pharmacy, University of Alexandria, Egypt.
Ph.D. Pharmacology, 2005, School of Medicine, East Carolina University, NC, USA.
Laboratory Department: Hypertension and Vascular Research Center, Obstetric and Gynecology Department
Email: hshaltou@wfubmc.edu
Advisors: Dr. Debra I Diz, Dr. Mark C Chappell
Current Research:
My research work is part of program project grant that investigates the long-term effects of antenatal exposure to glucocorticoids on renal function and blood pressure postnatally. Concurrent work focuses on the effect of antenatal glucocorticoids on brain renin angiotensin system (RAS), baroreceptor function and central neural mechanisms responsible for hypertension development in sheep. A second component of my work focuses on examining the impact of antenatal glucocorticoids on intra-renal RAS at different stages of development and the changes in RAS components especially angiotensin converting enzyme (ACE) and ACE2. Also I am working on measuring the effect of antenatal glucocorticoids on the RAS receptors subtypes distribution in the brain and kidney of sheep.
Publications:
Shaltout HA, Westwood BM, Averill DB, Ferrario CM, Figueroa JP, Diz DI, Rose JC and Chappell MC. Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II. American Journal of Physiology-Renal Physiology 2007;292:F82-F91.
Shaltout HA, Abdel-Rahman AA. Mechanism of fatty acids induced suppression of cardiovascular reflexes in rats, J Pharmacol Exp Ther. 2005 Sep;314(3):1328-37.
Shaltout HA, Abdel-Rahman AA. Cyclosporine induces progressive attenuation of baroreceptor heart rate response and cumulative pressor response in conscious unrestrained rats, J Pharmacol Exp Ther. 2003 Jun;305(3):966-73.
Abstracts:
Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Averill DB and Diz DI. Gender differences in the development of insulin resistance in adult sheep as result of antenatal betamethasone. Faseb Journal 21: A434, 2007
Shaltout HA, Figueroa JP, Rose JC, Chappell M, Diz DI and Averill DB. Antenatal betamethasone causes angiotensin II-mediated impairment of cardiovascular function. 60th Annual High Blood Pressure Research Conference, Austin TX, Oct 2006.
Shaltout HA, Figueroa JP, Rose JC, Chappell M, Diz DI and Averill DB. Antenatal betamethasone causes angiotensin II-mediated impairment of cardiovascular function. Hypertension 48: E32, 2006.
Shaltout HA, Figueroa JP, Rose JC, Averill DB, Diz DI and Chappell MC. Increased blood pressure is associated with lower serum ACE2 activity and higher ACE activity following antenatal steroid exposure. Journal of Hypertension 24: 127, 2006.
Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Diz DI and Averill DB. Antenatal betamethasone causes angiotensin II-mediated impairment of baroreflex control of heart rate. Journal of Hypertension 24: 159, 2006.
Shaltout HA, Westwood BM, Averill DB, Ferrario CM, Figueroa JP, Diz DI, Rose JC, Chappell MC. Predominance of ACE2-Dependent Metabolism of Angiotensin II but Not Angiotensin I In Sheep Renal Proximal Tubules and Urine. Faseb Journal. 2006; 20 (4):A765-A766.
Lodhi AM, Shaltout HA, Diz DI and Averill DB. Effects of Antenatal Glucocorticoids on Angiotensin Receptors in Fetal Sheep Kidney. State of North Carolina Undergraduate Research and Creativity Symposium November, 2006. P49
Shaltout HA, Abdel-Rahman AA. Immunosuppressants and the cardiovascular system: investigation by spectral analysis. 14th Annual Graduate Student Research day (March-2005).
Shaltout HA, Abdel-Rahman AA. Reduction in nonesterified fatty acids enhances baroreflex sensitivity and heart rate. Faseb Journal. 2005; 19(4):A102-A102.
Shaltout HA, Abdel-Rahman AA. Mechanism of immunosuppressants induced impairment of baroreflex sensitivity and heart rate variability. Faseb Journal. 2005; 19(4):A102-A103.
Shaltout HA, Abdel-Rahman AA. Inverse Relationship Between Plasma Non-esterified Fatty Acids and Spontaneous Baroreflex Sensitivity and Heart Rate Variability. Faseb Journal. 2004; 18(4):A602-A602.
Shaltout HA. Abdel-Rahman AA. Cyclosporine induces progressive attenuation of baroreceptor responsiveness and cumulative pressor response in conscious unrestrained rats. Faseb J, 2003;17(4): A112-A112.
Shaltout HA, Abdel-Rahman AA. Inverse Relationship Between Plasma Non-esterified Fatty Acids and Spontaneous Baroreflex Sensitivity and Heart Rate Variability. Twelfth Annual Graduate Student Research day, March 2003.
Shaltout HA, Abdel-Rahman AA. Cyclosporine induces progressive attenuation of baroreceptor responsiveness in conscious unrestrained rats. Eleventh annual research day, March 2002, page 18.
Contributed Talks:
Shaltout HA, Abdel-Rahman AA. Cyclosporine induces progressive attenuation of baroreceptor responsiveness in conscious unrestrained rats. Eleventh annual research day, March 2002.
Awards and Honors:
International Society of Hypertension Young Investigator Travel Grant to attend ISH2006 meeting in Fukuoka Japan, October 2006.
ASPET Young Scientist Travel Award to attend Experimental Biology Meeting, April 2006, San Francisco, CA.
Nominated as one of the four students from ECU to attend “A Gathering of Nobel Laureates: Science for the 21st century” in UNC Charlotte, Feb 28th 2005.
William Valentine Jr award for the best graduate student achievement in School of Medicine year 2004.
East Carolina University, School of Nursing Research Assistantship (Spring 2004)
ASPET Graduate Student Travel Award to attend the Experimental Biology Meeting, 2003. San Diego, CA.
East Carolina University, Department of Pharmacology Research Assistantship (Aug 2004- May 2005).
Egyptian Government Mission Scholarship to get the PhD in Pharmacology at School of Medicine, East Carolina University (Aug. 2000- Aug. 2004), (Government Mission Program).
Egyptian Pharmaceutical Companies Award for top graduate in pharmaceutical sciences (1993).