WILLIAM B. STRAWN, D.V.M., Ph.D.
Assistant Professor, Surgical Sciences, Hypertension and Vascular Research Center, Department of Physiology and Pharmacology
Medical Center Boulevard
Winston-Salem, NC 27157-1032
Tel: 336-716-9524
Fax: 336-716-2528
Email: bstrawn@wfubmc.edu
Pathobiology of Vascular Disease
Transgenic Rat Facility
Education:
Southern Methodist University, B.S., 1975
Louisiana State University Medical Center, New Orleans, Ph.D., 1981
Louisiana State University School of Veterinary Medicine, D.V.M., 1986
Research Description:
Inflammatory and Immune Processes in Vascular Disease
Atherosclerosis and Vascular Repair
Role of the Renin-Angiotensin System in Hematopoiesis
Current Research:
The laboratory investigates the contributions of bone marrow-derived hematopoietic and mesenchymal progenitor cells to the pathogenesis of vascular disease. Both in vivo and in vitro studies from the laboratory suggest that the renin-angiotensin system is a determining factor regulating bone marrow function in hypercholesterolemic patients and animal models of atherosclerosis. Dr. Strawn is the recipient of an American Heart Association Scientist Development Grant, and is a Fellow and member of the AHA Councils on High Blood Pressure Research (HBPR) and Arteriosclerosis, Thrombosis and Vascular Biology (ATVB).
Recent Publications:
Ferrario CM, Strawn WB. Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease. Am J Cardiol. 2006 Jul 1;98(1):121-8.
Strawn WB. Eplerenone antagonizes atherosclerosis, but what is the agonist? Hypertension. 2005 Nov;46(5):1093-4.
Igase M, Strawn WB, Gallagher PE, Geary RL, Ferrario CM. Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) expression in the aorta of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H1013-9.
Richmond RS, Tallant EA, Gallagher PE, Ferrario CM, Strawn WB. Angiotensin II stimulates arachidonic acid release from bone marrow stromal cells. J Renin Angiotensin Aldosterone Syst. 2004 Dec;5(4):176-82.
Strawn WB, Richmond RS, Tallant EA, Gallagher PE, Ferrario CM. Renin-angiotensin system expression in rat bone marrow hematopoietic and stromal cells. Br.J.Haematol 2004;126:120-126.
Ferrario CM, Richmond R, Smith RD, Levy P, Strawn W, Kivlighn S. Renin angiotensin system as a therapeutic target in managing atherosclerosis. Am J Thera 2004;11:44-53.
Strawn WB, Dean RH, Ferrario CM. Atherosclerosis and angiotensin II in hypercholesterolemia and diabetes. A role for AT1 receptors beyond hypertension. Atherosclerosis, Hypertension and Diabetes 2003; p 83-97. Series: Progress in Experimental Cardiology. Eds. GN Pierce, M Nagano, P Zahradka, and NS Dhalla, Kluwer Academic Publishers, Boston.
Ferrario CM, Smith R, Levy P, Strawn W. The Hypertension-Lipid Connection: Insights into the relation between angiotensin II and cholesterol in atherogenesis. Am J Med Sci 2002;323 (1):17-24.
Strawn WB.. Pathophysiological and clinical implications of AT1 and AT2 angiotensin receptors in metabolic disorders: hypercholesterolemia and diabetes. Drugs 2002;62 Spec Issue 1:31-41.
Strawn WB, Ferrario CM. Mechanisms linking angiotensin II and atherogenesis. Curr Opin Lipid 2002;13:505-512.
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine.