Ronald D. Smith, MD, FACP
Associate Professor, Section of General Surgery, Hypertension & Vascular Research Center, Internal Medicine/Nephrology, Director of Clinical Research - Hypertension and Vascular Research Center.
Janeway Clinical Sciences Building - 5th Floor.
Tel: 336-716-5819
Fax: 336-716-6644
E-mail: rosmith@wfubmc.edu
Education:
Northwestern University, Chicago, IL - MD – 1957
DePauw University, Greencastle, IN - BA - Liberal Arts/PreMed – 1953
Board Certified Internal Medicine and Nephrology
Research Description:
Hypertension, vascular endothelial dysfunction and its relationship to the renin-angiotensin system
Progression of renal disease
Ethical aspects of clinical research activities
Current Research:
Ongoing studies (VIOS, TROPHY, ACCOMPLISH, ONTARGET) test the theory of the importance of the renin-angiotensin system in maintaining the integrity of our blood vessels and the protection of our kidneys, brain and heart as we lower blood pressure with ACEI's and ARB's. The factors that are associated with this protection and how they can be appreciated and treated in the clinical setting are the focus of attention. Standard and novel approaches to the treatments for limiting the progression of renal disease using ACEI and ARB plus alternative medical products are under investigation. Dr. Smith has the patients for the use of ACE inhibitors for renal protection.
Recent Publications:
Ferrario CM, Smith RD. Cost-effectiveness of impedance cardiography testing in uncontrolled hypertension. Am Heart Hosp J. 2006 Fall;4(4):279-89.
Smith RD, Yokoyama H, Averill DB, Cooke L, Brosnihan KB, Schiffrin EL, Ferrario CM. The protective effects of angiotensin II blockade with olmesartan medoxomil on resistance vessel remodeling (The VIOS study): rationale and baseline characteristics.Am J Cardiovasc Drugs. 2006;6(5):335-42.
Ferrario CM, Smith RD. Response to Reduction of Blood Pressure Levels Study Group. Hypertension. 2006 Oct 2.
Smith RD, Levy P, Ferrario CM. Value of noninvasive hemodynamics to achieve blood pressure control in hypertensive subjects. Hypertension. 2006 Apr;47(4):771-7. Epub 2006 Mar 6.
Ferrario CM, Jessup J, Gallagher PE, Averill DB, Brosnihan KB, Tallant EA, Smith RD, Chappell MC. Effects of renin-angiotensin system blockade on renal angiotensin-(1-7) forming enzymes and receptors. Kidney Int. 2005 Nov;68(5):2189-96.
Yokoyama H, Averill DB, Brosnihan KB, Smith RD, Schiffrin El, Ferrario CM. Role of blood pressure reduction in prevention of cardiac and vascular hypertrophy.
Am J Hypertens. 2005 Jul;18(7):922-9.
Chen GJ, Smith RD, Ferrario CM. Association between antihypertensive agent use and hospital admissions in a managed care population. Am J Med Sci 2004;327(6):310-314.
Ferrario CM, Richmond RS, Smith RD, Levy P, Strawn WB, Kivlighn S. Renin-Angiotensin system as a therapeutic target in managing atherosclerosis. Am J Ther 2004;323(1):44-53.
Ferrario CM, Smith RD, Brosnihan KB, Chappell MC, Campese VM, Vesterqvist O, Liao WC, Ruddy MC, and Grim CE. Effects of omapatrilat on the renin-angiotensin system in salt-sensitive hypertension. Am J Hypertens 2002;15(6):557-64.
Ferrario CM, Smith RD, Levy P, Strawn W. The Hypertension-Lipid Connection: Insights into the relation between angiotensin II and cholesterol in atherogenesis. Am J Med Sci 2002;323(1):17-24.
Campese VM, Lasseter KC, Ferrario CM, Smith WB, Ruddy CM, Grim CE, Smith RD, Vargas R, Habashy MF, Vesterqvist O, Delaney C, Liao W. Omapatrilat vs. Lisinopril: Efficacy and neurohormonal profile in salt-sensitive hypertensive patients. Hypertension 2001;38:1342-1348.
Levy PJ, Yunis C, Owen J, Brosnihan KB, Smith RD, Ferrario CM. Inhibition of platelet aggregability by losartan in essential hypertension. Am J Cardiol 2000;86:1188-92.
Jones D, Basik J, Cushmon W, Egan B, Ferrario C, Hill M, Lackland D, Mensah G, Moore M, Ofili E, Rouella E, Smith RD, Taylor H. Managing Hypertension in the Southeastern United States: Applying the JNC VI Guidelines. Am J Med Sci 1999; 318:357-364.
Mitchell HC, Smith RD, Cutler RE, Sica D, Videen J, Thompson-Bell S, Jones K, Bradley-Guidry C, Toto RD. Racial differences in the renal response to blood pressure lowering during chronic angiotensin converting enzyme inhibition: A prospective double-blind randomized comparison of Fosinopril and Lisinopril in older hypertensive patients with chronic renal insufficiency. Am J Kid Dis 1997;29:897-906.
Toto R, Fenvas AZ, Mitchell HC, Mulcahey W, Smith RD. Effect of ramipril on blood pressure and protein excretion rate in normotensive non-diabetics with proteinuria. Am J Kid Dis 1996;28:832-840.
Toto R, Mitchell HC, Smith RD, McIntire D, Pettinger WA. Strict blood pressure control and progression of renal disease in hypertensive nephrosclerosis. Kid Int 1995;48:851-859.
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine.