MARK C. CHAPPELL, Ph.D.
Professor Surgical Sciences; Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Section of Molecular Medicine,
Hanes Building – 6th floor
Medical Center Boulevard Winston-Salem, NC 27157-1032
Tel: 336-716-9236
Fax: 336-716-2456
Email: mchappel@wfubmc.edu
Education:
American University, BS, 1986
Cleveland State University/Cleveland Clinic Foundation PhD, 1993
Research Description:
Biochemical and molecular aspects of the renin-angiotensin system
Sex differences in renal and cardiac injury
Role of estrogen in the development of salt-sensitive hypertension
Current Research:
His laboratory studies the role of the renin-angiotensin system in the regulation of blood pressure and the development of salt-dependent hypertension and tissue injury. The laboratory utilizes a multidisciplinary approach encompassing transgenic animal models, isolated tissue systems and primary and established cell lines to facilitate characterization of peptide hormones, their receptor proteins and the associated cell signaling pathways. Current areas of research focus on the marked sex differences in the development of hypertension and renal injury, particularly the role of the novel estrogen receptor GPR30. Dr. Chappell has published 7 book chapters, 100 manuscripts and over 120 abstracts concerning various aspects of the cardiovascular system. He receives current funding from the National Heart, Lung, and Blood Institute of the NIH and the American Heart Association.
Recent Publications:
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine.
Lindsey SH, Cohen JA, Brosnihan KB, Gallagher PA, Chappell MC. Chronic treatment with the GPR30 agonist G-1 decreases blood pressure in ovariectomized female mRen2.Lewis rats. Endocrinology, In press.
Gwathmey-Williams T, Shaltout HA, Pendergrass KD, Pirro NT, Figueroa JP, Rose JC, Diz DI, Chappell MC. Nuclear Angiotensin Type 2 (AT2) receptors are functionally linked to nitric oxide production. American Journal of Physiology. In press.
Shaltout HA, Figueroa JP, Rose JC, Diz DI, Chappell MC. Alterations in Circulatory and Renal Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 in Fetal Programmed Hypertension. Hypertension. 2009 53(2):404-408.
Garabelli PJ, Modrall JG, Penninger JM, Ferrario CM, Chappell MC. Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart. Experimental Physiology: 2008:93(5):613-621.
Chappell MC, Westwood BM, Yamaleyeva LM. Differential effects of sex steroids in young and aged female mRen2.Lewis rats: a model of estrogen and salt-sensitive hypertension. Gend Med. 2008;5 Suppl A:S65-75.
Pendergrass KD, Pirro NT, Westwood BM, Ferrario CM, Brosnihan KB, Chappell MC. Sex differences in circulating and renal angiotensins of hypertensive mRen(2).Lewis but not normotensive Lewis rats. Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H10-20