MARK C. CHAPPELL, Ph.D.
Associate Professor Surgical Sciences; Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Section of
Molecular Medicine,
Hanes Building – 6th floor
Medical Center Boulevard Winston-Salem, NC 27157-1032
Tel: 336-716-9236
Fax: 336-716-2456
Email: mchappel@wfubmc.edu
Education:
American University, BS, 1986
Cleveland State University/Cleveland Clinic Foundation PhD, 1993
Research Description:
Biochemical and molecular aspects of the renin-angiotensin system
Gender differences in renal and cardiac injury
Role of estrogen in the development of salt-sensitive hypertension
Current Research:
His laboratory studies the role of the renin-angiotensin system in the regulation of blood pressure and the development of salt-dependent hypertension and tissue organ injury. The laboratory utilizes a multidisciplinary approach encompassing transgenic animal models, isolated tissue systems and primary and established cell lines to facilitate characterization of peptide hormones, their receptor proteins and the associated cell signaling pathways. Current areas of research focus on the marked gender differences in the development of hypertension and renal injury. Dr. Chappell has published 7 book chapters, 65 manuscripts and over 100 abstracts concerning various aspects of the cardiovascular system. He receives current funding from the National Heart, Lung, and Blood Institute of the NIH and the American Heart Association.
Recent Publications:
Yamaleyeva LM, Gallagher PE, Vinsant S, Chappell MC. Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2.Lewis rats. Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R819-26.
Shaltout HA, Westwood BM, Averill DB, Ferrario CM, Figueroa JP, Rose JC, Diz DI, Chappell MC. Angiotensin metabolism in renal proximal tubules, urine and serum of sheep: Evidence for ACE2- dependent processing of angiotensin II. American J Physiology, 2007 Jan;292(1):F82-91.
Westwood, B. and Chappell, M. 2006. Application of correlate summation to data clustering in the estrogen- and salt-sensitive female mRen2.Lewis rat. In Proceedings of the 1st International Workshop on Text Mining in Bioinformatics (Arlington, Virginia, USA, November 10, 2006). TMBIO '06. ACM Press, New York, NY, 21-26. DOI= http://doi.acm.org/10.1145/1183535.1183542
Below is a zipped Excel template, which will perform the analyses described in the above paper for up to 100 variables for 4 groups of 15 subjects.
correlate summation template.zip
Chappell MC, Yamaleyeva LM, Westwood BM. Estrogen and salt-sensitivity in the female congenic mRen2.Lewis rat. American J Physiology, 2006 Jul 6.
Chappell MC and Ferrario CM. ACE and ACE2: Their contribution to the balance of expression of Ang II and Ang-(1-7). Kidney International, 70: 8-10, 2006.
Pendergrass KD, Averill DB, Ferrario CM, Diz DI, Chappell MC. Differential regulation of nuclear AT1 receptors and angiotensin II in the kidney of the mRen2.Lewis rat. American J Physiology 290:F1497-F1506, 2006.
Kuba K, Imai Y, Rao S, Gao, Guo F, Guan B, Huan Y, Yand P, Zhang Y, Deng W, Bao L, Zhang B, Kiu G, Wang Z, Liu Y, Zheng D, Leibbrandt A, Wada T, Chappell MC, Slutsky AS, Liu D, Quin C, Jiang C, Penninger JM. A critical role of ACE2 in SARS pathogenesis. Nature 11:875-879, 2005.
Chappell MC, Modrall JG, Diz DI, Ferrario CM. Novel aspects of the renal renin-angiotensin system: Angiotensin-(1-7), ACE2 and Blood Pressure Regulation. In: Contributions to Nephrology, “Kidney and Blood Pressure Regulation” (eds. H Suzuki and T Saruta), Karger, Basel 143:77-89, 2004.
Modrall JG, Sadjadi S, Hua CH, Kramer GL, Brosnihan KB, Gallagher PE, Bernstein KE, Chappell MC. Depletion of tissue ACE differentially influences the intrarenal and urinary expression of angiotensin peptides. Hypertension, 43:849-853, 2004.
Chappell MC, Gallagher PE, Averill DB, Ferrario CM, Brosnihan KB. Estrogen or the AT1 Antagonist Olmesartan Reverses the Development of Profound Hypertension in the Congenic mRen2.Lewis Rat. Hypertension. 2003 Jul 21
Neves LA, Averill DB, Ferrario CM, Chappell MC, Aschner JL, Walkup MP, Brosnihan KB. Characterization of angiotensin-(1-7) receptor subtype in mesenteric arteries. Peptides. 2003 Mar;24(3):455-62.
Brosnihan KB, Neves LA, Joyner J, Averill DB, Chappell MC, Sarao R, Penninger J, Ferrario CM. Enhanced Renal Immunocytochemical Expression of ANG-(1-7) and ACE2 During Pregnancy. Hypertension. 2003 Jul 21
Averill DB, Ishiyama Y, Chappell MC, Ferrario CM. Cardiac angiotensin-(1-7) in ischemic cardiomyopathy. Circulation 108:2141-2146, 2003.
Leung PS, Chappell MC. A local pancreatic renin-angiotensin system: endocrine and exocrine roles. International Journal of Biochemistry and Cell Biology, 35: 838-846, 2003.
Nakamura S, Averill DB, Chappell MC, Diz DI, Brosnihan KB, Ferrario CM. Angiotensin receptors contribute to blood pressure homeostasis in salt-depleted SHR Am J Physiol Regul Integr Comp Physiol. 2003 Jan;284(1):R164-73.
Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Bray MR, Backx PH, Chappell MC, Yagil Y, Penninger JM. Angiotensin-converting enzyme 2 is a negative regulator of renin-angiotensin system and controls heart function. Nature, 417:822-828, 2002.
Ferrario CM, Averill DB, Brosnihan KB, Chappell MC, Iskandar SS, Dean RH, Diz DI. Vasopeptidase inhibition and Ang-(1-7) in the spontaneously hypertensive rat. Kidney Int. 2002 Oct;62(4):1349-57.
Chappell MC, Allred AJ and Ferrario CM. Pathways for the metabolism of angiotensin-(1-7) in the kidney. Nephrol. Dial. Transplant 16: S22-26, 2001.
Chappell MC, Diz DI and Gallagher PE. The renin-angiotensin system and the exocrine pancreas. Journal of the Pancreas 2: 33-39, 2001.
Allred AJ, Diz DI, Ferrario CM and Chappell MC. Pathways for angiotensin-(1-7) metabolism in pulmonary and renal tissues. Am J Physiol: Renal 279: F841-F850, 2000.
Allred AJ, Chappell MC, Ferrario CM and Diz DI. Differential actions of renal ischemic injury on the intrarenal angiotensin system. Am J Physiol: Renal, 279:F636-645, 2000.
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine.