K. BRIDGET BROSNIHAN, Ph.D.
Professor Surgical Sciences; Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Department of Obstetrics and Gynecology, Section of Molecular Medicine, Neuroscience Program. Director of the Hypertension Core Laboratory. Co-Director of the Molecular Medicine Graduate Program.
Hanes Building – 6th floor
Medical Center Boulevard
Winston-Salem, NC 27157-1032
Tel: 336-716-2795
Fax: 336-716-2456
Email: bbrosnih@wfubmc.edu
Education:
College of St. Mary, BS, 1965
Creighton University, MS, 1970
Case Western Reserve University Medical School, PhD, 1974
Research Description:
Neuroendocrine aspects of hypertension
Vascular biology
Pregnancy and hormone replacement
Current Research:
Her laboratory studies the role of hormones in the control of blood pressure and vascular reactivity. She uses physiological and pharmacological approaches to study cardiovascular and hormonal consequences of pregnancy and the role of estrogen. Biochemical methods allow the measurement of tissue and circulating levels of neuroendocrine hormones. Research approaches in her laboratory study the mechanism of synthesis and secretion of angiotensin peptides from a number of local tissues. Dr. Brosnihan has published over 18 chapters and 100 manuscripts. She has maintained an uninterrupted record of funding from the National Heart, Lung, and Blood Institute of the NIH from 1984.
Recent Publications:
Smith RD, Yokoyama H, Averill DB, Cooke L, Brosnihan KB. The protective effects of angiotensin II blockade with olmesartan medoxomil on resistance vessel remodeling (The VIOS study): rationale and baseline characteristics. Am J Cardiovasc Drugs. 2006;6(5):335-42.
Lange La, Burdon K, Langefeld CD, Liu Y, Beck SR, Rich SS, Freedman Bi, Brosnihan KB, Herrington DM, Wagenknecht LE, Bowden DW. Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study. Ann Hum Genet. 2006 Nov;70(Pt 6):717-25.
Neves LA, Chappell MC, Ferrario CM, Gallagher PE, Ganten D, Brosnihan KB. Effect of estrogen on neprilysin expression in uterus and kidney of Sprague-Dawley normotensive and heterozygous (mRen2)27-transgenic hypertensive rats. Peptides. 2006 Nov;27(11):2912-8.
Jessup JA, Gallagher PE, Averill DB, Brosnihan KB, Tallant EA, Chappell MC, Ferrario CM. Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats. Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2166-72.
Bowden DW, Lange LA, Langefeld CD, Brosnihan KB, Freedman BI, Carr JJ, Wagenknecht LE, Herrington DM. The relationship between C-reactive protein and subclinical cardiovascular disease in the Diabetes Heart Study (DHS). Am Heart J. 2005 Nov;150(5):1032-8.
Yokoyama H, Averill DB, Brosnihan KB, Smith RD, Schiffrin El, Ferrario CM. Role of blood pressure reduction in prevention of cardiac and vascular hypertrophy.
Am J Hypertens. 2005 Jul;18(7):922-9.
Sane DC, Anton L, Brosnihan KB. Angiogenic growth factors and hypertension. Angiogenesis. 2004;7(3):193-201.
Neves LA, Averill DB, Ferrario CM, Aschner JL, Brosnihan KB. Vascular responses to Angiotensin-(1-7) during the estrous cycle. Endocrine. 2004 Jul;24(2):161-5.
Brosnihan KB, Neves LA, Anton L, Joyner J, Valdes G, Merrill DC. Enhanced expression of Ang-(1-7) during pregnancy. Braz J Med Biol Res. 2004 Aug;37(8):1255-62.
Chappell MC, Gallagher PE, Averill DB, Ferrario CM, Brosnihan KB. Estrogen or the AT1 Antagonist Olmesartan Reverses the Development of Profound Hypertension in the Congenic mRen2.Lewis Rat. Hypertension. 2003 Jul 21 [Epub ahead of print]
Brosnihan KB, Neves LA, Joyner J, Averill DB, Chappell MC, Sarao R, Penninger J, Ferrario CM. Enhanced Renal Immunocytochemical Expression of ANG-(1-7) and ACE2 During Pregnancy. Hypertension. 2003 Jul 21 [Epub ahead of print]
Neves LA, Williams AF, Averill DB, Ferrario CM, Walkup MP, Brosnihan KB. Pregnancy enhances the angiotensin (Ang)-(1-7) vasodilator response in mesenteric arteries and increases the renal concentration and urinary excretion of Ang-(1-7). Endocrinology. 2003 Aug;144(8):3338-43.
Neves LA, Averill DB, Ferrario CM, Chappell MC, Aschner JL, Walkup MP, Brosnihan KB. Characterization of angiotensin-(1-7) receptor subtype in mesenteric arteries. Peptides. 2003 Mar;24(3):455-62.
Abdelhamed AI, Reis SE, Sane DC, Brosnihan KB, Preli RB, Herrington DM. No effect of an L-arginine-enriched medical food (HeartBars) on endothelial function and platelet aggregation in subjects with hypercholesterolemia. Am Heart J. 2003 Mar;145(3):E15.
Nakamura S, Averill DB, Chappell MC, Diz DI, Brosnihan KB, Ferrario CM. Angiotensin receptors contribute to blood pressure homeostasis in salt-depleted SHR. Am J Physiol Regul Integr Comp Physiol. 2003 Jan;284(1):R164-73.
Merrill DC, Karoly M, Chen K, Ferrario CM, Brosnihan KB. Angiotensin-(1-7) in normal and preeclamptic pregnancy. Endocrine. 2002 Aug;18(3):239-45.
Ferrario CM, Averill DB, Brosnihan KB, Chappell MC, Iskandar SS, Dean RH, Diz DI. Vasopeptidase inhibition and Ang-(1-7) in the spontaneously hypertensive rat. Kidney Int. 2002 Oct;62(4):1349-57.
Herrington DM, Howard TD, Brosnihan KB, McDonnell DP, Li X, Hawkins GA, Reboussin DM, Xu J, Zheng SL, Meyers DA, Bleecker ER. Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein. Circulation. 2002 Apr 23;105(16):1879-82.
Herrington DM, Howard TD, Hawkins GA, Reboussin DM, Xu J, Zheng SL, Brosnihan KB, Meyers DA, Bleecker ER. Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease. N Engl J Med. 2002 Mar 28;346(13):967-74
Fukuhara M, Neves LA, Li P, Diz DI, Ferrario CM, Brosnihan KB. The angiotensin II AT1 receptor antagonist irbesartan prevents thromboxane A2-induced vasoconstriction in the rat hind-limb vascular bed in vivo. J Hypertens. 2001 Mar;19(3 Pt 2):561-6.
Levy PJ, Yunis C, Owen J, Brosnihan KB, Smith R, Ferrario CM. Inhibition of platelet aggregability by losartan in essential hypertension. Am J Cardiol. 2000 Dec 1;86(11):1188-92.
Brosnihan KB, Senanayake PS, Li P, Ferrario CM. Bi-directional actions of estrogen on the renin-angiotensin system. Braz J Med Biol Res. 1999 Apr;32(4):373-81.
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine.