CARLOS M FERRARIO, M.D.
Professor and Director,
Hypertension and Vascular Research Center
Professor, Department of Physiology/Pharmacology
Wake Forest University School of Medicine
President and CEO,
Consortium for Southeastern Hypertension Control
Medical Center Boulevard
Winston-Salem, NC 27157-1032
Tel: 336-716-5819
Fax: 336-716-6644
E-mail: cferrari@wfubmc.edu
Center for Excellence in Hypertension and Vascular Research |
Education:
M Moreno College, Argentina, BA, 1956
University of Buenos Aires School of Medicine, MD, 1963
Research Description:
Cardiovascular Medicine
Hemodynamics of Hypertension
Hormonal Regulation of Blood Pressure
Vascular Disease
Current Research:
Elucidation of the mechanisms of hypertensive vascular disease by combining laboratory efforts with clinical investigation utilizing molecular, genetic, and physiological approaches to the characterization of cardiac and blood vessel remodeling;
Study of the function of angiotensin peptides, with special emphasis on angiotensin-(1-7) in the regulation of blood pressure;
Analysis of the mechanism of action of antihypertensive drugs such as angiotensin converting enzyme inhibitors and angiotensin II antagonists in reversing the cardiac and vascular sequelae of hypertension and the metabolic syndrome.
Dr. Ferrario has published 400 papers to-date in the field of hypertension and vascular disease. He serves as officer and member of many professional societies and has been bestowed multiple national and international awards.
He is the Founder of the Consortium for Southeastern Hypertension Control (COSEHC), an organization which has pioneered medical and educational efforts directed to reduce cardiovascular deaths in the South.
Recent Publications:
Ferrario CM, Smith RD; CONTROL Trial Investigators. Cost-effectiveness of impedance cardiography testing in uncontrolled hypertension. Am Heart Hosp J. 2006 Fall;4(4):279-89.
Sakima A, Averill DB, Kasper So, Jackson LM, Ganten D, Ferrario CM, Gallagher, PE, Siz DI. Baroreceptor Reflex Regulation in Anesthetized Transgenic Rats with Low Glial-Derived Angiotensinogen. Am J Physiol Heart Circ Physiol. 2006 Nov 3;
Smith RD, Yokoyama H, Averill DB, Cooke L, Brosnihan KB, Schiffrin EL, Ferrario CM. The protective effects of angiotensin II blockade with olmesartan medoxomil on resistance vessel remodeling (The VIOS study): rationale and baseline characteristics. Am J Cardiovasc Drugs. 2006;6(5):335-42.
Ferrario CM. Role of angiotensin II in cardiovascular disease therapeutic implications of more than a century of research. J Renin Angiotensin Aldosterone Syst. 2006 Mar;7(1):3-14. Review.
Chappell MC, Ferrario CM. ACE and ACE2: their role to balance the expression of angiotensin II and angiotensin-(1-7). Kidney Int. 2006 Jul;70(1):8-10.
Ferrario CM. Highlights of the Twelfth Annual COSEHC National Scientific Session. Am J Med Sci. 2006 Feb;331(2):59.
Ferrario CM. Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation. Hypertension. 2006 Mar;47(3):515-21. Epub 2005 Dec 19.
Ferrario CM, Trask AJ, Jessup JA. Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function. Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2281-90.
Sakima A, Averill DB, Gallagher PE, Kasper SO, Tommasi EN, Ferrario CM, Diz DI. Impaired heart rate baroreflex in older rats: role of endogenous angiotensin-(1-7) at the nucleus tractus solitarii. Hypertension. 2005 Aug;46(2):333-40.
Tallant EA, Ferrario CM, Gallagher PE. Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor. Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1560-6.
Ferrario CM, Chappell MC. Novel angiotensin peptides. Cell Mol Life Sci. 2004 Nov;61(21):2720-7.
Ferrario CM, Chappell MC. Angiotensin formation and degradation. Hypertension Primer, Third Edition. Lippincott Williams & Wilkins. Joseph Izzo and Henry R. Black, Sr Eds. Philadelphia, 2003;19-21.
Strawn WB, Dean RH, Ferrario CM. Atherosclerosis and angiotensin II in hypercholesterolemia and diabetes. A Role for AT1 receptors beyond hypertension. In: Grant N. Pierce, Makoto Nagano, Peter Zahradka, Naranjan S. Dhalla, Eds Atherosclerosis, Hypertension and Diabetes Kluwer Academic Publishers. Boston. 2003:83-97.
Ferrario CM. Management of the hypertensive patient with sexual dysfunction. In: Egan BM, Basile JN, Lackland DT, Eds Hot Topics: Hypertension . Hanley & Belfus, Inc. Philadelphia 2003:345-357.
Chen GJ, Smith RD, Gerth W, Ferrario CM, Association between antihypertensive agent utilization and hospital admissions in a managed care population. Am J Med Sciences. 2004;327(6):310-314.
Strawn WB, Richmond RS, Tallant EA, Gallagher PE, Ferrario CM. Renin-angiotensin system expression in rat bone marrow haematopoietic and stromal cells. British J of Haematology. 2004;126:120-126.
Ishiyama Y, Gallagher PE, Averill DB, Tallant EA, Brosnihan KB, Ferrario CM. Up-regulation of angiotensin converting enzyme 2 induced by losartan alter myocardial infarction. Hypertension 2004;43:970-976.
Ferrario CM, Abdelhamed AI, Moore M. AII antagonists in hypertension, heart failure, and diabetic nephropathy: focus on losartan. Current Medical Research and Opinion. 2004;20(3):279-293.
Ferrario CM, Richmond R, Smith RD, Levy P, Strawn W, Kivlighn S. Renin-angiotensin system as a therapeutic target in managing atherosclerosis. Am J Therapeutics. 2004:11(1):44-53.
Ferrario CM. Contribution of Angiotensin-(1-7) to cardiovascular physiology and pathology. Current Hypertension Reports. 2003;5(2):129-134.
Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, DaCosta J, Pei Y, Scholey J, Ferrario CM, Chappell MC. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 2002;417:822-828.
Articles/Journals
Effects of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2. Circulation 2005; 111:2605-2610 May 2005.
For a listing of additional publications, refer to PubMed, a service provided by the National Library of Medicine.