Publications & Data

This page provides press releases, abstracts, and supplemental data regarding publications from the Center for Human Genomics. These articles are organized by category of research.

Pulmonary Disease

"Effect of ADRB2 polymorphisms on response to longacting β2-agonist therapy: a pharmacogenetic analysis of two randomised studies", Lancet, January 2008.

Prostate Cancer

"Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans"

S. Lilly Zheng, Jielin Sun,  Yu Cheng, Ge Li, Fang-Chi Hsu, Yi Zhu, Bao-li Chang, Wennuan Liu, Jin Woo Kim, Aubrey R. Turner, Marta Gielzak, Guifang Yan, Sarah D. Isaacs, Kathleen E. Wiley, Jurga Sauvageot, Huann-Sheng Chen, Robin Gurganus, Leslie A. Mangold, Bruce J. Trock, Henrik Gronberg, David Duggan, John D. Carpten, Alan W. Partin, Patrick C. Walsh, Jianfeng Xu, William B. Isaacs. JNCI, In Press.

• 8q24 supplemental data - primers (18Kb excel file)  Primer information for 18 primers used to perform sequnom iPLEX reactions as described in the manuscript.

"Multiple genomic alterations on chromosome 21q22 predict various TMPRRS2:ERG fusion transcripts in human prostate cancers".

Liu, Ewing, Chang, Li, Sun, Turner, Dimitrov, Zhu, Sun, Kim, Zheng, Isaacs, and Xu.  Genes, Chromosomes and Cancer, In Press.

• TMPRSS2-ERG_Supplementary_Table1  (820KB excel file) Using allele-specific analysis we analyzed a total of 41 pairs of samples from primary prostate tumors and matched nonmalignant tissues as described above with 16 tumors harboring T-E deletion.
• TMPRSS2-ERG_Supplementary_Table2 (4.3MB excel file) We used a 3-SNP genomic smoothing approach to reduce the noise of the raw data in order to identify the breakpoint SNPs.

"Integration of somatic deletion analysis of prostate cancers and germline linkage analysis of prostate cancer families reveals two small consensus regions for prostate cancer genes at 8p". Cancer Res. 2007 May 1;67(9):4098-103.

• 8p supplemental data (14.5MB excel file)  This data is the log2 ratio of 10-SNP average, estimated from CNAG2.0 analysis and presented for each SNP at 8p.

"A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS study". Prostate. 2006 Oct 1;66(14):1556-64.

• Inflammation pathway paper supplementary data (2006) for paper published in Prostate

"HD6 Polymorphism in Macrophage-Inhibitory Cytokine-1 Gene Is Associated with Prostate Cancer":

• Supplemental Data for Journal of the National Cancer Institute article
• MIC-1 abstract, August 2004 in JNCI
• MIC-1 Full article on JNCI site (subscription required)

Combined Genome-Wide Scan for Prostate Cancer Susceptibility Genes

• Genome wide screen abstract, August 2004 in JNCI
• G.W.S. Full article on JNCI site (subscription required)

Interaction effect of PTEN and CDKN1B chromosomal regions on prostate cancer linkage.

• Link to Pubmed abstract
• PDF Reprint of Article on Human Genetics site (subscription required)

Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study:

• Link to Pubmed abstract
• Pubmed abstract of April 2004 article in Cancer Research
• PDF Reprint of Article on CR site (subscription required)

Discovery of MSRI as a prostate cancer gene:

• Supplemental data for Am.J.Hum.Gen. article--common variants in MSR1
• Supplemental data for Nature Genetics article--high risk variants in MSR1

Departure from HWE as a screen for genotyping error:

• Supplemental Data for Human Genetics article

Cardiovascular Disease

Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease.

Herrington DM, Howard TD, Hawkins GA, Reboussin DM, Xu J, Zheng SL, Brosnihan KB, Meyers DA, Bleecker ER.

• [link to press release]
• [link to PUBMED abstract]
• [link to supplemental data]

Cystic Fibrosis and Pseudomonas

Pseudomonas aeruginosa Flagellin and Alginate Elicit Very Distinct Gene Expression Patterns in Airway Epithelial Cells: Implications for Cystic Fibrosis Disease.
Cobb LM, Mychaleckyj JC, Wozniak DJ, Lopez-Boado YS.
J Immunol. 2004 Nov 1;173(9):5659-5670.

• Statistical Methods--A more detailed description of the statistical methods used for microarray analysis. 
•  Supplementary Data - Detailed strain group comparison data sets available for download.
• The full data set is also available at NCBI GEO, Series GSE923: