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Center for Human Genomics at Wake Forest University School of Medicine

Stephen P. Peters, M.D., Ph.D.
Professor of Medicine
Research Director, Pulmonary and Critical Care Medicine

Yale University B.A. 1971 Chemistry (high honors, magna cum laude)
University of Pittsburgh School of Medicine Ph.D. 1976 Biochemistry (Advisor: Robert H. Glew, Ph.D.)
University of Pittsburgh School of Medicine M.D. 1978 AOA, cum laude

Clinical Interests
Asthma and obstructive lung diseases. ARDS.

Research Interests
Human models of asthma
Epithelial cell – mesenchymal cell interactions in airway remodeling in asthma
Clinical trials in asthma.

Selected Publications

Peer Reviewed

Zangrilli, J., Robertson, N.M., Shetty, A., Wu, J., Hastie, A.T., Fish, J.E., Litwack, G., Peters, S.P. Effect of IL-5, glucocorticoid, and Fas ligation on Bcl-2 homologue expression and caspase activation in circulating human eosinophils. Clin. Exp. Immunol. 120:12-21, 2000.

Fahy, J.V., Boushey, H.A., Lazarus, S.C., Mauger, E.A., Cherniack, R.M., Chinchilli, V.M., Drazen, J.M., Ford, J.G., Fish, J.E., Israel, E., Kraft, M., Lemanske, R.F., Jr., Martin, R.J., McLean, D., Peters, S.P., Sorkness, C., Szefler, S.J., for the National Heart, Lung, and Blood Institute’s Asthma Clinical Research Network. Safety and reproducibility of sputum induction in asthma subjects in a multicenter study. Am. J. Respir. Crit. Care Med. 163:1470-1475, 2001.

Israel, E., Drazen, J.M., Liggett, S.B., Boushey, H.A., Cherniack, R.M., Chinchilli, V.M., Cooper, D.M., Fahey, J.V., Fish, J.E., Ford, J.G., Kraft, M., Kunselman, S., Lazarus, S.C., Lemanske, R.F., Jr., Martin, R.J., McLean, D.E., Peters, S.P., Silverman, E.K., Sorkness, C.A., Szefler, S.J., Weiss, S.T., Yandava, C.N, for the National Heart, Lung, and Blood Institute’s Asthma Clinical Research Network. The effect of polymorphisms of the b2-adrenergic receptor on the response to regular use of albuterol in asthma. Am. J. Respir. Crit. Care Med. 162:75-80, 2000.

Colavita, A.M., Hastie, A.T., Musani, A.I., Pascual, R.M., Reinach, A.J., Lustine, H.T., Galati, S.A., Zangrilli, J.G., Fish, J.E., Peters, S.P. Kinetics of IL-10 production after segmental antigen challenge of atopic asthmatics.
J. Allergy Clin. Immunol. 106:880-886, 2000.

Ammit, A.J., Hastie, A.T., Edsall, L.C., Hoffman, R.K., Krymskaya, V.P., Kane, S.A., Peters, S.P., Penn, R.B., Spiegel, S., Panettieri, R.A., Jr. Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. FASEB J. 15:1212-1214. 2001.

Lazarus, S.C., Boushey, H.A., Fahy, J.V., Chinchilli, V.M., Lemanske, R.F., Jr., Sorkness, C.A., Kraft, M., Fish, J.E., Peters, S.P., Craig, T., Drazen, J.M., Ford, F.G., Israel, E., Martin, R.J., Mauger, E.A., Nachman, S.A., Spahn, J.D., Szefler, S.J. for the National Heart, Lung, and Blood Institute’s Asthma Clinical Research Network. Long-acting b2-agonist monotherapy vs continuous therapy with inhaled corticosteroids in patients with persistent asthma. A randomized controlled trial. JAMA 285:2583-2593, 2001.

Lemanske, R.F., Jr., Sorkness, C.A., Mauger, E.A., Lazarus, S.C., Boushey, H.A., Fahy, J.V., Drazen, J.M., Chinchilli, V.M., Craig, T., Fish, J.E., Ford, J.G., Israel, E., Kraft, M., Martin, R.J., Nachman, S.A., Peters, S.P., Spahn, J.D., Szefler, S.J., for the National Heart, Lung, and Blood Institute’s Asthma Clinical Research Network. Inhaled corticosteroids reduction and elimination in patients with persistent asthma receiving salmeterol. A randomized controlled trial. JAMA 285:2594-2603, 2001.

Leone, F.T., Mauger, E.A., Peters, S.P., Chinchilli, V.M., Fish, J.E., Boushey, H.A., Cherniack, R.M., Drazen, J.M., Fahy, J.V., Ford, J., Israel, E., Lazarus, S.C., Lemanske, R.F., Martin, R.M., McGeady, S.J., Sorkness, C., Szefler, S.J., for the Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute. The utility of peak flow, symptom scores, and b-agonist use as outcome measures in asthma clinical research. Chest 119:1027-1033, 2001.

Pascual, R.M., Billington, C.K., Hall, I.P., Panettieri, Jr., R.A., Fish, J.E., Peters, S.P., Penn, R.B. Mechanisms underlying cytokine effects on G protein-coupled receptor-mediated signaling and functions in airway smooth muscle. Am. J. Physiol. Lung Cell. Mol. Physiol. 281: L1425-L1435, 2001.

American Lung Association Asthma Clinical Research Centers. [S. Peters]. The safety of inactivated influenza vaccine in adults and children with asthma. N. Engl. J. Med. 345:1529-1536, 2001.

Loza, M.J., Peters, S.P., Zangrilli, J.G., Persussia, B. Distinction between IL-13+ and IFN-g+ natural killer cells and regulation of their pool size by IL-4. Eur. J. Immunol. 32:413-423, 2002.

Martin, R.J., Szefler, S.J., Chinchilli, V.M., Kraft, M., Dolovich, M., Eng, P., Boushey, H.A., Cherniack, R., Craig, T.J., Drazen, J.M., Fagan, J., Fahy, J.V., Fish, J.E., Ford, J., Israel, E., Kunselman J., Lazarus, S.C., Lemanske, R.F., Jr., Peters, S.P., Sorkness, C., for the National Heart, Lung, and Blood Institute’s Asthma Clinical Resarch Network. Systemic effect comparisons of six inhaled corticosteroid preparations. Am. J. Respir. Crit. Care Med. 165:1377-1383, 2002.

Szefler, S.J., Martin, R.J., King, T.S., Boushey, H.A., Cherniack, R., Chinchilli, V.M., Drazen, J.M., Fish, J.E., Fagan, J., Fahy, J.V., Ford, J., Hurd, S., Israel, E., Kiley, J., Kraft, M., Lazarus, S.C., Lemanske, R.F., Maugher, E., Peters, S.P., Sorkness, C., for the National Heart, Lung, and Blood Institute’s Asthma Clinical Resarch Network. Significant variability in response to inhaled corticosteroids for persistent asthma. J. Allergy Clin. Immunol. 109:410-418, 2002.

Hastie, A.T., Kraft, W.K., Nyce, K.B., Zangrilli, J.G., Musani, A.I., Fish, J.E., Peters, S.P. Asthmatic epithelial cell proliferation and stimulation of collagen production. Human asthmatic epithelial cells stimulate collagen type III production by human lung myofibroblasts after segmental allergen challenge. Am. J. Respir. Crit. Care Med. 165:266-272, 2002.

Robertson, N.M., Zangrilli, J.G., Steplewski, A., Hastie, A., Lindemeyer, R.G., Planeta, M.A., Smith, M.K., Innocent N., Musani, A., Pascual, R., Peters, S., Litwack, G. Differential expression of TRAIL and TRAIL receptors in allergic asthmatics following segmental antigen challenge: Evidence for a role of TRAIL in eosinophil survival. J. Immunol. 169:1986-5996, 2002.

Reviews and Book Chapters

Zangrilli, J.G., Peters, S.P. Cytokines in allergic airway disease.
In: Asthma and Rhinitis, 2nd Ed. (Eds.: W.W. Busse, S.T. Holgate). Blackwell Science Ltd., Malden, MA, pp. 577-596, 2000.

Colavita, A.M., Reinach, A.J., Peters, S.P. Contributing factors to the pathobiology of asthma. The Th1/Th2 paradigm. Clin. Chest Med. 21:263-277, 2000.

Hastie, A.T., Peters, S.P. Interactions of allergens and irritants in susceptible populations in producing lung dysfunction: Implications for future research. In: Inhaled Environmental/Occupational Irritants and Allergens: Mechanisms of Cardiovascular and Systemic Responses. (Eds.: D.B. Yeates, ) Environmental Health Perspectives 109 (suppl 4):605-607, 2001.

Lieberman, P., Calhoun, W.J., Panettieri, R.A., Jr., Peters, S.P., Rennard, S.I. Asthma and irreversible lung disease. Remodeling-fact or fiction? Medical Crossfire 3:30-43, 2001.

Musani, A.I., Pascual, R.M., Peters, S.P. Asthma. In: Manual of Allergy and Immunology, 4th Ed.: (Eds.: D.C. Adelman, T.B. Casale, J. Corren). Lippincott Williams & Wilkins, Philadelphia, PA, pp. 93-137, 2002.
Awsare, B., Peters, S.P. Status asthmaticus. In: Current Therapy in Allergy, Immunology and Rheumatology, 6th Ed. (Eds.: L.M. Lichtenstein, W.W. Busse, R.S. Geha). Mosby, Inc., Philadelphia, PA, pp. XX. (In press).

Schulman, E.S., Yassin, R.R., Peters, S.P. Mechanisms of mast cell activation. In: Asthma and Rhinitis, 2nd Ed. (Eds.: W.W. Busse, S.T. Holgate). Blackwell Science Ltd., Malden, MA, pp. 296-310, 2000.

Peters, S.P. The distal lung in asthma: An under appreciated but emerging area in asthma pathogenesis and treatment. Perspective in MD Consult, January 16, 2002.

Israel, E., Drazen, J.M., Liggett, S.B., Boushey, H.A., Cherniack, R.M., Chinchilli, V.M., Cooper, D.M., Fahey, J.V., Fish, J.E., Ford, J.G., Kraft, M., Kunselman, S., Lazarus, S.C., Lemanske, R.F., Jr., Martin, R.J., McLean, D.E., Peters, S.P., Silverman, E.K., Sorkness, C.A., Szefler, S.J., Weiss, S.T., Yandava, C.N, for the National Heart, Lung, and Blood Institute’s Asthma Clinical Research Network. Effect of polymorphisms of the b2-adrenergic receptor on the response to regular use of albuterol in asthma. Int. Arch. Allergy Immunol. 124:183-186, 2001.

Batra, V., Peters, S.P. Leukotriene modifiers as monotherapy for asthma. Harrison’s Online 2002.

Batra, V., Niazi, S., Peters, S.P. Persistent asthma: What approach is best? J. Respir. Dis. 23: 330-340, 2002.

Niazi, S., Batra, V., Awsare, B., Zangrilli, J.G., Peters, S.P. Initiation, Progression, and Resolution of Allergic Inflammation. In: Allergy: Principles and Practice, 6th Ed. (Eds.: N.F. Adkinson, Jr., W.W. Busse, C.E. Reed, E.F. Ellis, J.W. Yunginger). Mosby, St. Louis, pp. (In press).

Peters, S.P. Approach to the Treatment of Severe Asthma. Resp. Digest 4:1-11, 2002.

Peters, S.P. Leukotriene receptor antagonists in asthma therapy. J. Allergy Clin. Immunol. 111:S62-S70, 2003.

Peters, S.P. Asthma in the 21st Century: Definition, Inflammatory Processes, Heterogeneity, and Consequences of Chronic Airway Inflammation. Am. J. Med. (In press).

Fish, J.E., Peters, S.P. Bronchial challenge testing. In: Allergy: Principles and Practice, 6th Ed. (Eds.: N.F. Adkinson, Jr., W.W. Busse, C.E. Reed, E.F. Ellis, J.W. Yunginger). Mosby, St. Louis, pp. (In press).