Patrick P. Koty, M.D.
Associate Professor of Pediatrics

Research Interests

Research interests include the genetics of breast cancer.

Selected Publications: Journal Articles

Kim PK, Park SY, Koty PP, Hua Y, Luketich JD, Billiar TR. Fas-associating death domain protein overexpression induces apoptosis in lung cancer cells. J Thorac Cardiovasc Surg. 2003 Jun;125(6):1336-42.

Koty PP, Zhang H, Lei W, Levitt ML. Isolation of cells entering different programmed cell death pathways using a discontinuous Percoll gradient. Methods Mol Med. 2003;74:309-26.

Lei W, Koty PP, Levitt ML. Relationship of EGFR signal-transduction modulation by tyrosine kinase inhibitors to chemosensitivity and programmed cell death in lung cancer cell lines. Methods Mol Med. 2003;74:127-43.

Koty PP, Lei W, Levitt ML. Induction of programmed cell death with an antisense Bcl-2 oligonucleotide. Methods Mol Med. 2003;75:671-84.

Koty PP, Tyurina YY, Tyurin VA, Li SX, Kagan VE. Depletion of Bcl-2 by an antisense oligonucleotide induces apoptosis accompanied by oxidation and externalization of phosphatidylserine in NCI-H226 lung carcinoma cells. Mol Cell Biochem. 2002 May-Jun;234-235(1-2):125-33.

Koty PP, Zhang H, Franklin WA, Yousem SA, Landreneau R, Levitt ML. In vivo expression of p53 and Bcl-2 and their role in programmed cell death in premalignant and malignant lung lesions. Lung Cancer. 2002 Feb;35(2):155-63.

Levitt ML, Koty PP. Tyrosine kinase inhibitors in preclinical development. Invest New Drugs. 1999;17(3):213-26. Review.

Koty PP, Zhang H, Levitt ML. Antisense bcl-2 treatment increases programmed cell death in non-small cell lung cancer cell lines. Lung Cancer. 1999 Feb;23(2):115-27.

Zhang H, Koty PP, Mayotte J, Levitt ML. Induction of multiple programmed cell death pathways by IFN-beta in human non-small-cell lung cancer cell lines. Exp Cell Res. 1999 Feb 25;247(1):133-41.

Koty PP, Pegoraro E, Hobson G, Marks HG, Turel A, Flagler D, Cadaldini M, Angelini C, Hoffman EP. Myotonia and the muscle chloride channel: dominant mutations show variable penetrance and founder effect. Neurology. 1996 Oct;47(4):963-8.

Chartrain NA, Geller DA, Koty PP, Sitrin NF, Nussler AK, Hoffman EP, Billiar TR, Hutchinson NI, Mudgett JS. Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene. J Biol Chem. 1994 Mar 4;269(9):6765-72.