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Center for Human Genomics at Wake Forest University School of Medicine

Donald Bowden, Ph.D.
Associate Director, Center for Human Genomics
Professor of Biochemistry and Internal Medicine
Section of Endocrinology and Metabolism

B.A., 1972 Vanderbilt University
Ph.D., 1978 University of California - Berkeley

Research Interests

Research in our laboratory is focused on efforts to identify human genes which contribute to common diseases in our population. We use a wide range of molecular genetic techniques, including linkage and association studies with polymorphic DNA sequences, physical mapping of chromosomes, and functional analysis of candidate disease genes and the proteins for which they code. The long term focus of the laboratory has been genetic analysis of diabetes, especially Type 2 diabetes (non-insulin dependent diabetes mellitus, NIDDM, adult onset diabetes) and complications of diabetes such as diabetic nephropathy and cardiovascular disease. Projects range from a focused molecular genetic effort to identify diabetes genes in a small region of chromosome 20 q12-q13.1, to evaluation of whether genes contribute to the development of diabetic cardiovascular disease using sophisticated clinical methods to quantify cardiovascular disease (e.g., radiological measurement of
coronary artery quantification).

Selected Publications

Bensen JT, Li L, Langefeld CD, McCall CE, Cousart SL, Dryman BN, Freedman BI, Bowden DW. Association of an IL1A 3’UTR Polymorphism with End Stage Renal Disease and IL1? Expression, Kidney International, in press

Hirakawa S, Freedman BI, Lange EM, Colicigno C, Rich SS, Bowden DW. Evaluation of genetic variation and linkage disequilibrium in the matrix metalloproteinase 9 gene, MMP9, in end stage renal disease patients. Am. J. Kidney Disease, in press

Bowden DW. Genetics of Renal Disease. Kidney International, 63 S83 S8-S12 (2003)

Yu H, Song Q, Freedman, Chao J, Chao L, Bowden DW. Association of the Tissue Kallikrein Gene Promoter with ESRD and Hypertension. Kidney International, 61: 1030-1039 (2002)

Bowden DW. Genetics of Diabetes Complications. Current Diabetes Reports 2: 191-200 (2002)

Gitter J, Langefeld CD, Rich SS, Pedley CF, Bowden DW, Freedman BI. The prevalence of nephropathy in black patients with Type 2 diabetes mellitus. J Am Soc Nephrology, Am J Nephrol. 22: 35-41(2002)

Herrington DM, Vittinghoff E, Howard TD, Major DA, Owen J, Reboussin DM, Bowden DW, Bittner V, Simon J, Grady D, Hulley SB. Factor V Leiden, hormone replacement therapy, and risk of venous thromboembolic events in women with established coronary disease. Arterioscl Thromb & Vasc Biol. 22:1012-1017 (2002)

Lange LA, Bowden DW, Carr JJ, Langefeld CD, Wagenknecht LE, Rich SS, Riley WA, Freedman BI. Heritability of carotid artery intimal medial thickness in type 2 diabetes. Stroke 33: 1876-1881 (2002)

Freedman BI, Rich SS, Yu H, Roh BH, Bowden DW. Linkage heterogeneity of end stage renal disease on human chromosome 10. Kidney International 62:770-774 (2002)

Satko SG, Langefeld CD, Daeihagh P, Bowden DW, Rich SS, Freedman BI. Nephropathy in siblings of African-Americans with overt Type 2 diabetic nephropathy. Am J of Kidney Diseases 40:489-494 (2002)

Sale MM, FitzGerald LM, Charlesworth JC, Bowden DW, Rich SS. Evidence for a novel type 1 diabetes susceptibility locus on chromosome 8. Diabetes 51 Suppl 3:S316-9 (2002)

Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW. Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. Journal of Interferon and Cytokine Research, 21: 899-904 (2001)

Dawson PA, Mychaleckyj J, Fossey SA, Mihic SJ, Craddock AL, Bowden DW. Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes susceptibility linked region of chromosome 20q12-13.1. Mol Gen Metab, 74: 186-199 (2001).

Fossey SA, Mychaleckyj J, Snyder JR, Pendleton JA, Bowden DW: A high resolution 7mb transcript map of the type 2 diabetes susceptibility locus on human chromosome 20q12-13.1. Genomics, 76:45-57 (2001).

Wagenknecht LE, Bowden DW, Carr JJ, Langefeld CD, Freedman BI, Rich SS.: Familial aggregation of coronary artery calcium in families with type 2 diabetes. Diabetes, 50:861-866 (2001).

Fossey SC, Kuroda S, Price JA, Brewer CC, Freedman BI, Bowden DW.: Identification of a candidate RACK gene in 20q12-q13.1. Mammalian Genome, 11:919-25 (2000).

Yu H, Anderson PJ, Freedman BI, Rich SS, Bowden DW.: Genomic structure of the human plasma prekallikrein gene, identifcation of allelic variants, and analysis in
End-Stage Renal Disease. Genomics 69:225-34 (2000).

Price JA, Fossey SC, Sale MM, Brewer CS, Freedman BI, Weurth J-P, Bowden DW.: Analysis of the HNF4a gene in Caucasian Type 2 diabetic nephropathic patients.
Diabetologia, 43:364-372 (2000).

Hart TC, Walker SJ, Bowden DW, Hart PS, Callison SA, Bobby PL, Firatli E.: An integrated physical and genetic map of the PLS locus interval on chromosome 11q14.
Mammalian Genone 11:243-246 (2000).

Yu H, Freedman BI, Rich SS, Bowden DW. (2000) Human Na+/H+ exchanger genes: identification of polymorphisms by radiation hybrid mapping and analysis of linkage in
End-Stage Renal Disease. Hypertension 35: 135-143.