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Center for Human Genomics at Wake Forest University School of Medicine

Deborah A. Meyers, Ph.D.
Co-Director, Center for Human Genomics
Section Head, Medical Genetics, Department of Pediatrics
Professor of Pediatrics and Public Health
Professor of Medicine

B.A., 1971 Ithaca College
Ph.D., 1976 Indiana Univ.
Fellowship, 1976-1978: Univ. of North Carolina

Teaching Interests

Human Genetics and Genomics; Inheritance of Common Diseases

Research Interests

Gene mapping in common complex diseases as well as in Mendelian disorders, ascertainment and characterization of relevant families, DNA genotyping, linkage and association analyses, positional cloning and in analytical methods.

Selected Publications

Xu J. Bleecker ER, Jongepier H. Howard TD, Koppelman GH, Postma DS, Meyers DA. Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12. Am J of Hum Genet 2002; 71:646-650.

Hawkins GA, Mychaleckyj JC, Zheng SL, Faith DA, Kelly B, Isaacs SD, Wiley KE, Chang B, Ewing CM, Bujnovszky P, Bleecker ER, Walsh PC, Meyers DA Isaacs WB, Xu J. Germline Sequence Variants of the LZTS1 Genes are associated with prostate cancer risk. Cancer Genet Cytogent 2002; 137:1-7.

Xu J, Zheng SL, Mychaleckyj J, Isaacs SD, Faith DA, Hu JJ, Sterling D, Lange E, Hawkins GA, Turner A, Ewing CM, Johnson JR, Komiya A, Bujnovszky P, Wiley KE, DeMarzo A, Chang B, Hall MC, McCullough DL, Partin A, Kassabian VS, Carpten J, Bailey-Wilson J, Trent JM, Ohar J, Bleecker ER, Walsh PC, Isaacs WB, Meyers DA. Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. Nature Genet 2002; 32:321-5

Xu J, Turner A, Little J, Bleecker ER, Meyers DA. Positive results in association studies are associated with departure from Hardy-Weinberg Equilibrium: hint for genotyping error? Human Genet 2002. (Advance Online Publicaton 13 September, 2002).

Zheng SL, Mychaleckyj JC, Hawkins GA, Isaacs SD, Wiley KE, Turner A, Chang B, von Kap-Herr C, Carpten JD, Pettenati M, Bleecker ER, Walsh PC, Trent JM, Meyers DA, Isaacs WB, Xu J. Evaluation of DLC1 as a prostate cancer susceptibility gene: mutation screen and association study. Mut Res 2002. In Press. .

Howard TD, Postma DS, Hawkins GA, Koppelman GH, Zheng SL, Xu J, Meyers DA, Bleecker ER. Fine-mapping of an IgE controlling gene on chromosome 2q: analysis of CTLA-4 and CD28. J Allergy Clin Immunol 2002. In Press.

Koppelman GH, Jansen DF, Schouten JP, van der Heide S, Bleecker, ER, Meyers DA, Postma DS. Sibling effect on atopy in children of patients with asthma. Clinic Exp Allergy 2002. In Revision.

Chang B, Zheng SL, Isaacs DS, Hawkins GA, Turner A, Wiley KE, Bleecker ER, Walsh PC, Meyers DA, Isaacs WB. Polymorphisms in the CYP1A1 gene are associated with prostate cancer risk. Int J of Cancer 2002 Submitted.

Chang B, Zheng SL, Isaacs SD, Turner A, Hawkins GA, Wiley KE, Bleecker ER, Walsh PC, Meyers DA, Isaacs WB, Xu J. Poly morphisms in the CYP1B1 gene are associated with increased risk of prostate cancer. Human Genetics 2002 Submitted.

Chang B, Zheng SL, Isaacs SD, Turner AR, Bleecker ER, Walsh PC, Meyers DA,
Isaacs WB, Xu J. Evaluation of SRD5A2 sequence variants insusceptibility to hereditary and sporadic prostate cancer. The Prostate 2002 Submitted.

Hsing AW, Zheng SL, Gao YT, Deng J, Sesterhenn IA, Mostofi FK, Meyers DA, Isaacs WI, and Xu J. HPC2/ELAC2 susceptibility and prostate cancer risk: a population based control study in China. 2002 Submitted.

Hawkins GA, Cramer S, Zheng SL, Isaacs SD, Wiley KE, Chang B, Bleecker ER, Walsh PC, Meyers DA, Isaacs WB, Xu J. Sequence variants in the human 25-Hydroxyvitamin D31- -Hydroxylase (CYP27) gene are not associated with prostate cancer risk. The Prostate 2002; 53:175-178.
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Colilla S, Nicolae D, Pluzhnikov A, Blumenthal MN, Beaty TH, Meyers DA, Lange E, Rich SS, Bleecker ER, Ober C, Cox NJ and the CSGA. Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure. J Allergy Clin Immunol 2002. Submitted.

Rao A, Chang B, Hawkins GA, Hu JH, Rosser CJ, Hall MC, Meyers DA, Xu J, Cramer SD. Functional and population-based analysis of the G/A polymorphism in the androgen response element I of the PSA gene and its interaction with the androgen receptor polymorphisms. Urology 2002 In Press.

Xu J, Zheng SL, Komiya A, Mychaleckyj JC, Isaacs DS, Chang B, Turner AR, Ewing CM, Wiley KE, Hawkins GA, Bleecker ER. Walsh PC, Meyers DA, Isaacs WB. Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. Am J Hum Genet 2002 Submitted.

Zheng SL, Chang B, Isaacs SD, Turner A, Wiley KE, Bleecker ER, Walsh PC, Meyers DA, Isaacs WB, Xu J. Sequence variants of a-Methylacyl-CoA Racemase are associated with prostate cancer risk. Cancer 2002 Submitted.

Blumenthal MN, Langefeld DC, Beaty TH, Bleecker ER, Over C, Lester L, Lange E, Barnes KC, Wolf R, King RA, Solway J, Oetting W, Meyers DA, Rich SS for NHLB1 Collaborative Study on theGenetics of Asthma. A genome-wide search for allergic response (atopy) genes in three ethnic groups: collaborative studyon the genetics of asthma (CSGA). 2002 Submitted.

Chatterjee AR, Wiesch DG, Meyers DA, Paigen BJ, Samet JM, Eggleston PA, Xu J, Bleecker ER. A mouse-related laboratory animal allergy survey in 815 at risk subjects. 2002 In preparation.

Amelung PJ, Hawkins GA, Bleecker ER, Koppelman G, Jongepier, Hawkins G, Whittaker P, Meyers DA, Postma DS. Polymorphisms in the glucocorticoid receptor gene: prevalence and relevance in asthma. 2002 In Preparation.